Friday, June 28, 2013

Try These Great Tips For Your Home Improvement Project ...

Home improvement is likely an engaging topic for nearly every homeowner. Everyone wants their home to look great; however, undertaking a large improvement project can be overwhelming. Read this article to learn what you need to know about the basics of home improvement.

Changing air filters is paramount. This will bring in healthier air and keep your air conditioners and heaters running efficiently. Many service calls are placed each year because of dirty filters.

If you are running out of counter space in your kitchen, consider an over-the-range microwave. You can find these type of microwave ovens in a variety of prices. Many of them have special features like convection cooking. A lot of units use a filter and not a vent; these are meant for those who do not need a lot of ventilation.

It is important that you focus your improvement work on the visible portions of your home. Potential buyers base their judgment on things they see, and having unsightly things such as cracked and peeling paint or a yard overgrown with weeds can be a cause for them to walk from a good deal. It is very true that a lot of home improvments cannot be seen but you need to take care of the ones that can be seen first.

In many home improvement projects, using ?premium? materials is a way to maximize the value of the work. Comparison shop for these building supplies before choosing a vendor! It can cost a lot of money to install a new floor, so be sure to shop around to find the best deals. There are supply stores that give out discount and you could also look for bargain places that could help you.

As you read in the beginning of this article, improving your home is not as scary as it may seem. The skills you learn in one renovation project make future projects much easier to take on. Follow our tips to be ready for the next home improvement project that presents itself.

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Source: http://www.poolbuildersinorlando.com/try-these-great-tips-for-your-home-improvement-project/

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Tuesday, June 11, 2013

Obama to nominate Furman as top economic adviser

President Barack Obama talks to family members standing on the Truman balcony of the White House as he walks from Marine One on the South Lawn after returning to Washington, Sunday, June 9, 2013. Obama spent the weekend in California where he met with Chinese leader Xi Jinping. (AP Photo/Susan Walsh)

President Barack Obama talks to family members standing on the Truman balcony of the White House as he walks from Marine One on the South Lawn after returning to Washington, Sunday, June 9, 2013. Obama spent the weekend in California where he met with Chinese leader Xi Jinping. (AP Photo/Susan Walsh)

(AP) ? President Barack Obama will nominate Jason Furman, a veteran White House economic official, as chairman of the president's Council of Economic Advisers.

The White House says Obama will make the announcement Monday afternoon.

The council is one of two of the president's main sources of economic advice to the president. The other is the National Economic Council, where Furman currently serves as principal deputy director.

If confirmed by the Senate, Furman would replace Alan Krueger, who is returning to his former post as a professor at Princeton University.

Furman's research has been focused on fiscal and tax policy, Social Security and monetary policy. Furman, 42, worked as an economist in the Clinton White House and before that was a senior adviser at the World Bank.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-10-Obama-Economist/id-ef0618d5a1cd49619ed26616822a549c

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Jury selection begins in George Zimmerman trial

George Zimmerman, accused in the Trayvon Martin shooting, in Seminole Circuit Court during his pretrial hearing??

Lawyers on both sides of the George Zimmerman trial Monday began what is expected to be a weekslong process of selecting a 12-member jury in the incendiary case in Sanford, Florida.

As potential jurors filled out questionnaires, Judge Debra Nelson denied a request from Zimmerman's attorneys to delay the start of the trial for several weeks on grounds they needed more time to prepare.

His attorneys declined to ask for a change of venue in the case, suggesting they are confident they can find impartial jurors in the area despite the wall-to-wall media coverage that 17-year-old Trayvon Martin's killing attracted last year.

But his brother, Robert Zimmerman, didn't sound convinced. "We're obviously concerned about that," he told reporters Monday when asked if he believed George Zimmerman could get a fair trial.

Zimmerman, out on $1 million bond and in hiding for much of the past year, is charged with second-degree murder for killing the unarmed teen in a confrontation in his gated community, where Zimmerman acted as a volunteer watchman.

Prosecutors argue that Zimmerman racially profiled, followed and then shot Martin. Zimmerman's lawyers counter that their client was attacked by Martin and that he acted in self-defense.

Defense lawyer Jose Baez, who represented Casey Anthony in her high-profile trial in Orlando in 2011, said jury selection in this trial will be especially complicated because of the case's racial overtones. (Zimmerman identifies himself as Hispanic; Martin was black.)

Martin's family hinted at the potential complications in a statement released Monday morning.

"Trayvon's life was taken unnecessarily and tragically, but we call upon the community to be peaceful. We have placed our faith in the justice system and ask that the community do the same," the family wrote.

Generally, defense lawyers would be more likely than prosecutors to want to select minorities for a jury, since, on average, African-American and Hispanic people express more skepticism of law enforcement than white people, according to Baez. But in this case, Zimmerman's defense lawyers will want to pack the jury with white "gun-toting Republicans" who would be amenable to their argument that their client shot and killed the unarmed Martin in self-defense, Baez said.

These jurors might also be more convinced by the argument that local police made the right decision not to arrest or charge Zimmerman in the shooting initially.

"It's a very unique case in that respect, where the general rules that a lot of lawyers use are just going be absolutely flipped upside down," Baez said. "Because it is such a racially charged case, I think that the clear line is going to be drawn here between African-American jurors and Caucasian and Hispanic jurors."

But the defense team will have to be very careful in its quest to find conservative jurors more amenable to the self-defense argument. Circuit Judge Debra Nelson, who is presiding over the televised trial in the Seminole County Courthouse, will most likely be vigilant to make sure neither side is excluding jurors based on their race, which is illegal under a 1985 Supreme Court decision.

"I think this judge is fully aware of the racial tensions involved and is going to be on high alert," Baez said. If the defense team moves to dismiss an African-American juror during the peremptory strike phase of jury selection, for example, the judge could challenge it to provide a reason for the move. If the team can't come up with a good reason (for example, that the juror attended a rally in support of Trayvon Martin), the judge will assume the attorneys wanted to dismiss the juror for racial reasons and override their preference.

Nelson has ruled that the pool of 500 potential jurors will be kept anonymous during the selection process. It's possible she could order them sequestered during the trial, which is what happened to the jurors in the Anthony case. Nelson rejected the defense's request to sequester them during jury selection.

The pool will shrink rapidly as jurors can make the case that sitting on a jury for weeks would be a hardship. After that process winnows down the lot, the attorneys will go through and disqualify anyone with a personal connection to the case. Both sides will be on the lookout for jurors who have stated their support for either Zimmerman or Martin on social media sites, or been involved in activism around the case. The attorneys may also have potential jurors fill out questionnaires gauging their beliefs about gun control, law enforcement, race and other issues.

Yahoo's Jason Sickles contributed reporting.

Source: http://news.yahoo.com/blogs/lookout/jury-selection-begins-george-zimmerman-trial-121304344.html

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Interferon-beta aids balance and movement in mice with spinocerebellar ataxia 7; first in vivo study of the treatment for this condition shows significant physical improvement

June 9, 2013 ? The first in vivo trial of the use of interferon-beta in a mouse model of the group of fatal diseases known as spinocerebellar ataxia has shown that its use can significantly improve their physical condition and control symptoms. Researchers in France and the US believe that their results show that a clinical trial in humans is merited.

The group of genetic conditions known as spinocerebellar ataxias currently have no treatment or cure and are always fatal, in the case of affected children at an early age. Symptoms include a progressive lack of co-ordination of gait, and poor co-ordination of hands, speech and eye movements, due to a failure of co-ordination of muscle movements. Now researchers from France and the US have found a new way of controlling the symptoms and significantly improving the physical condition of animal models of the disease, the annual conference of the European Society of Human Genetics will hear today (Monday June 10).

Dr. Annie Sittler, from the Centre National de la Recherche Scientifique (CNRS), working in the team of Professor Alexis Brice at the research centre Brain and Spinal Cord Institute (CR-ICM), Paris, France described the team's work in the field of polyglutamine disease, a group of neurodegenerative conditions involving abnormal protein conformation. "Accumulation of a polyglutamine-containing protein known as mutant ataxin -7 is responsible for neurotoxicity, neuronal dysfunction, and eventually neuronal death," she explains. "We had previously shown in cells that mutant ataxin-7 was degraded in nuclear bodies, structures found in the nucleus of cells, by a protein known as promyeloctyic leukemia protein or PML, and that interferon-beta could help with this process and protect against disease."

The researchers used a mouse model of a particular form of spinocerebellar ataxia known as SCA7. The genetically-modified 'knock-in' mice develop the severe type of the disease, similar to the infantile human version, and have a very short lifespan of around 14 weeks. They were injected with mouse interferon-beta three times a week, starting at five weeks of age, just before their first symptoms of disease were due to appear. Investigation of their brains post-mortem showed that the mice who had received the interferon-beta, as opposed to those in the control group, had a reduced load of mutant ataxin-7.

On the physical level, substantial improvements in the interferon-beta treated mice were noticed. "At twelve weeks of age the physical performance of the mice that received the active substance was significantly improved compared to the control group. We gave them a locotronic test, where they have to cross a kind of ladder. This test is used to check motor co-ordination when walking. We also put them through a beam-walking test, which enables us to measure their balance and limb co-ordination. The treated mice did much better in both of these tests," Dr. Sittler will say.

Further proof of the positive effects of interferon-beta came from analysis of the PML nuclear bodies, involved in many cellular processes such as transcriptional regulation and apoptosis. A subset of these nuclear bodies is responsible for regulating the degradation of accumulated misfolded proteins in the cell nucleus. The treated mice had more, and very much larger, PML bodies, and they were present in the Purkinje cells, responsible for motor co-ordination emanating from the cerebellum The researchers further found that these PML bodies were clastosomes, the specialised nuclear bodies involved in the degradation of mutant ataxin-7 and other polyglutamine-containing proteins. "This, together with the physical improvements we saw in the interferon-beta treated mice, was the proof we needed that our findings in the cell could be successfully transferred to living animals," says Dr. Sittler.

"Now that we have found that interferon-beta can slow progression of disease in SCA7 mice, we believe that, after confirmation in another mouse model, it would be merited to test its effects on humans in a clinical trial,," she will say. "Such trials are difficult in rare diseases, since a special design is needed to test a hypothesis on a small number of patients. However, there are a number of other polyglutamine diseases, for example Huntington's, where patient numbers are larger, and the effects of the condition just as devastating. We hope that our results will encourage others to collaborate with us in order that we may be able to pursue our research to the benefit of all those afflicted with spinocerebellar disorders."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/SHfKGHW_WWg/130609195625.htm

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Friday, June 7, 2013

World's Oldest Tumor Found In a Neanderthal Bone

First time accepted submitter minty3 writes "A fibrous dysplasia tumor has been found in the bone of a Neanderthal that is more than 120,000 years old. The world's oldest tumor in a Neanderthal rib was part of a collection of bones, which were excavated more than 100 years ago from a site in Krapina, Croatia. They were X-rayed in the 1980s, and initially didn't reveal the tumor. It was only when scientists took a closer look at a radiograph where a rib fragment appeared to be 'burned out' did they return to the rib and subject it to higher quality scans."

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/YaRtxl98Vzo/story01.htm

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